American Board of Internal Medicine (ABIM) Certification Practice Exam

What percentage of patients with primary sclerosing cholangitis have ulcerative colitis?

1. 50%

2. 60%

3. 70%

4. 80%

The correct answer is: 80%

Primary sclerosing cholangitis (PSC) is a liver disease characterized by the progressive inflammation and scarring of the bile ducts. It has a strong association with inflammatory bowel disease, particularly ulcerative colitis (UC). Research indicates that a significant majority of patients diagnosed with PSC also have underlying UC. The correct percentage indicating that 80% of patients with PSC have ulcerative colitis reflects this established association. The relationship is considered robust, and many studies have consistently reported that around 70% to 80% of individuals with PSC eventually develop ulcerative colitis, often preceding or occurring alongside their liver condition. This association provides important clinical insights, as healthcare providers often screen for gastrointestinal symptoms in patients with PSC due to the high prevalence of UC. Consequently, recognizing the connection between these two conditions is vital for managing and monitoring affected patients effectively.