American Board of Internal Medicine (ABIM) Certification Practice Exam

What is the most common adverse effect associated with levetiracetam?

1. Drowsiness

2. Irritability

3. Dizziness

4. Nausea

The correct answer is: Irritability

The most common adverse effect associated with levetiracetam is irritability. Levetiracetam is an anticonvulsant medication frequently prescribed to treat epilepsy. One of its unique characteristics is that it can affect mood and behavior. While other listed side effects such as drowsiness, dizziness, and nausea do occur, irritability is particularly notable among levetiracetam users, especially in the pediatric population. Irritability may stem from the drug's impact on neurotransmitter systems in the brain, which can alter how patients express their moods and handle stress. This side effect has often led to discontinuation or the need for monitoring mood changes during treatment. Understanding this side effect is crucial for clinicians when they are prescribing levetiracetam, as they must be prepared to address any behavioral changes that may emerge in their patients.