American Board of Internal Medicine (ABIM) Certification Practice Exam

What is the current consensus on pharmacologic treatment for cognitive dysfunction in multiple sclerosis?

1. No proven therapy

2. Benzodiazepines

3. SSRIs

4. Tricyclic antidepressants

The correct answer is: No proven therapy

The consensus regarding pharmacologic treatment for cognitive dysfunction in multiple sclerosis (MS) indicates that there currently is no proven therapy specifically approved for this condition. Cognitive impairment in MS is recognized as a significant concern, affecting daily functioning and quality of life, but the available evidence does not support the efficacy of any specific medication class in treating cognitive dysfunction associated with MS. While medications like benzodiazepines, SSRIs, and tricyclic antidepressants are used to manage other symptoms of MS, such as anxiety, depression, or pain, there is a lack of conclusive data demonstrating their effectiveness in directly improving cognitive function in this patient population. Research efforts continue to explore potential treatments, but as of now, the focus typically remains on supportive care and cognitive rehabilitation strategies rather than specific pharmacologic interventions. This reinforces the stance that, at present, no therapy has been established as effective for treating cognitive dysfunction in MS.