American Board of Internal Medicine (ABIM) Certification Practice Exam

Washed platelets are typically reserved for patients who have had which type of reaction to platelet transfusion?

1. Severe allergic reactions

2. Minimal adverse reactions

3. None allergic reactions

4. Moderate allergic reactions

The correct answer is: Severe allergic reactions

Washed platelets are specifically utilized for patients who have experienced severe allergic reactions to platelet transfusions. This process involves removing plasma proteins and other potential allergens from platelets, which minimizes the risk of further allergic reactions in these sensitized individuals. In cases of severe allergic reactions, such as anaphylaxis, patients may have heightened sensitivity to components found in donor platelets, particularly the proteins in plasma. By washing the platelets, healthcare providers significantly reduce the risk of a repeat reaction, ensuring safer transfusions for those patients. Those who experience minimal or moderate allergic reactions typically do not require washed platelets, as their reactions can often be managed through other means, such as antihistamines or premedication. Non-allergic reactions may involve different physiological responses and do not necessitate the washing process, which is specifically aimed at addressing allergic sensitivities.