American Board of Internal Medicine (ABIM) Certification Practice Exam

At what age should APC gene carriers begin yearly flexible sigmoidoscopy or colonoscopy?

1. 5 to 10 years

2. 10 to 15 years

3. 15 to 20 years

4. 20 to 25 years

The correct answer is: 10 to 15 years

For individuals who are carriers of a mutation in the APC gene, screening for colon cancer is particularly important due to the high risk of developing familial adenomatous polyposis (FAP), which can lead to numerous polyps and ultimately colorectal cancer if not monitored and managed appropriately. The recommended age to begin regular screenings, such as flexible sigmoidoscopy or colonoscopy, is typically between 10 to 15 years. This age range allows for early detection of any polyps that may start to develop in adolescents, even before symptoms may arise. Beginning screening at this earlier age helps ensure that any potential issues can be identified and addressed before they develop into more serious complications. While guidelines may adapt over time, the consensus in current medical literature suggests starting at this age for optimal surveillance of colorectal health in APC gene carriers. This proactive approach is crucial for effective management and has been demonstrated to improve outcomes significantly.